On February 28, 2020, 24 Novichok precursors were added to the Australia Group (AG) Chemical Weapons Precursors list, to complement the recent addition of Novichok agents to CWC Schedule 1.
The added Novichok precursors include AG entries 66-72 – phosphorus-containing precursors for the synthesis of phosphate agents listed in CWC 1A14, e.g. A-232 and A-234 – and AG entries 73-89 – amidine precursors for the synthesis of CWC 1A13 and CWC 1A14. The phosphorus-containing precursors for the synthesis of the phosphonate agents listed in CWC 1A13 (e.g. A-230) and CWC 1A15 (A-242) were already part of the AG chemical precursors list prior to the amendment, as they coincide with the precursors for canonical nerve agents.
The table below lists the new entries added to the AG Chemical Weapons Precursors list, curated and structurally annotated.
New. The table is now downloadable in SDF, CSV, and Microsoft Excel format.
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Update to Australia Group Chemicals
Curated and Structurally Annotated by Costanzi Research – www.costanziresearch.com (Last Update: November 15, 2022) The Table is available for download in the following formats: SDF, CSV, Microsoft Excel |
Disclaimer. The information in this table is provided for research and general information purposes only. The authors do not guarantee the accuracy of the information and do not take any responsibility for any consequence, including, but not limited to, financial or legal consequences, that may occur due to inaccuracies or omissions. |
| Color Code: |
Individual Chemicals Mixtures of Chemicals Proteins Families of Chemicals Examples: Individual Compounds Belonging to a Family of Chemicals Exceptions: Compounds Belonging to a Family of Chemicals but Excluded from the CWC Schedules |
Notes. 1. Entries 66-89 were added on February 28, 2020. 2. CAS Registry Numbers® are the intellectual property of the American Chemical Society; and are used by Licensee with the express permission of CAS. CAS Registry Numbers® are Verified by CAS unless noted by a *. For entries lacking a CAS Registry Number®, a sequential registry number assigned by Costanzi Research (CR number) is provided instead. 3. For proteins, the UNIPROT ID is provided instead. 4. Overlaps among CWC schedules, Australia Group chemicals, and Wassenaar ML7 chemicals are provided. 5. 2D structures curated by Costanzi Research are provided as SDF and MRV files (MRV files require ChemAxon’s MarvinSketch to open). 6. 3D strucures from PubChem are shown with NCBI’s iCn3D. 7. NIST Chemistry WebBook cards provide chemical and physical data compiled by the National Institute of Standards and Technology, including, inter alia, analytical spectra. |
| Category | AG Entry Number1 | AG Entry Name | CAS Registry Number®2 | PubChem ID3 | Structure (click to enlarge) |
SMILES | InChI | Overlaps4 | Links5-7 |
|---|---|---|---|---|---|---|---|---|---|
| Novichok precursor | AG 66 | Methyl dichlorophosphate | 677-24-7 | 69611 |
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CO[P](Cl)(Cl)=O | InChI=1S/CH3Cl2O2P/c1-5-6(2,3)4/h1H3 InChIKey=SNVCRNWSNUUGEA-UHFFFAOYSA-N |
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| Novichok precursor | AG 67 | Ethyl dichlorophosphate | 1498-51-7 | 15158 |
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CCO[P](Cl)(Cl)=O | InChI=1S/C2H5Cl2O2P/c1-2-6-7(3,4)5/h2H2,1H3 InChIKey=YZBOZNXACBQJHI-UHFFFAOYSA-N |
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| Novichok precursor | AG 68 | Methyl difluorophosphate | 22382-13-4 | 123401 |
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CO[P](F)(F)=O | InChI=1S/CH3F2O2P/c1-5-6(2,3)4/h1H3 InChIKey=ZLTVJTLCEBCPRC-UHFFFAOYSA-N |
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| Novichok precursor | AG 69 | Ethyl difluorophosphate | 460-52-6 | 120250 |
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CCO[P](F)(F)=O | InChI=1S/C2H5F2O2P/c1-2-6-7(3,4)5/h2H2,1H3 InChIKey=CNDDYKSDJBKASR-UHFFFAOYSA-N |
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| Novichok precursor | AG 70 | Diethyl chlorophosphite | 589-57-1 | 68530 |
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CCOP(Cl)OCC | InChI=1S/C4H10ClO2P/c1-3-6-8(5)7-4-2/h3-4H2,1-2H3 InChIKey=TXHWYSOQHNMOOU-UHFFFAOYSA-N |
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| Novichok precursor | AG 71 | Methyl chlorofluorophosphate | 754-01-8 | 23418492 |
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CO[P](F)(Cl)=O | InChI=1S/CH3ClFO2P/c1-5-6(2,3)4/h1H3 InChIKey=GUDIWCZJEDSHOE-UHFFFAOYSA-N |
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| Novichok precursor | AG 72 | Ethyl chlorofluorophosphate | 762-77-6 | 23416048 |
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CCO[P](F)(Cl)=O | InChI=1S/C2H5ClFO2P/c1-2-6-7(3,4)5/h2H2,1H3 InChIKey=GKMSNBMXTVUSFQ-UHFFFAOYSA-N |
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| Novichok precursor | AG 73 | N,N-Dimethylformamidine | 44205-42-7 | 12669390 |
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CN(C)C=N | InChI=1S/C3H8N2/c1-5(2)3-4/h3-4H,1-2H3 InChIKey=DSWNRHCOGVRDOE-UHFFFAOYSA-N |
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| Novichok precursor | AG 74 | N,N-Diethylformamidine | 90324-67-7 | 17912027 |
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CCN(CC)C=N | InChI=1S/C5H12N2/c1-3-7(4-2)5-6/h5-6H,3-4H2,1-2H3 InChIKey=WJPHKKLZKLZWDB-UHFFFAOYSA-N |
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| Novichok precursor | AG 75 | N,N-Dipropylformamidine | 48044-20-8 | 87832225 |
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CCCN(CCC)C=N | InChI=1S/C7H16N2/c1-3-5-9(7-8)6-4-2/h7-8H,3-6H2,1-2H3 InChIKey=BLDHGACEPAYSQL-UHFFFAOYSA-N |
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| Novichok precursor | AG 76 | N,N-Diisopropylformamidine | 857522-08-8 | 19782034 |
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CC(C)N(C=N)C(C)C | InChI=1S/C7H16N2/c1-6(2)9(5-8)7(3)4/h5-8H,1-4H3 InChIKey=ZQRAQDIQRXIIGH-UHFFFAOYSA-N |
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| Novichok precursor | AG 77 | N,N-Dimethylacetamidine | 2909-14-0 | 6394935 |
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CN(C)C(C)=N | InChI=1S/C4H10N2/c1-4(5)6(2)3/h5H,1-3H3 InChIKey=PAXRVGDTBDATMF-UHFFFAOYSA-N |
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| Novichok precursor | AG 78 | N,N-Diethylacetamidine | 14277-06-6 | 4243241 |
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CCN(CC)C(C)=N | InChI=1S/C6H14N2/c1-4-8(5-2)6(3)7/h7H,4-5H2,1-3H3 InChIKey=RXSIKRLQGANXCL-UHFFFAOYSA-N |
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| Novichok precursor | AG 79 | N,N-Dipropylacetamidine | 1339586-99-0 | 62047941 |
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CCCN(CCC)C(C)=N | InChI=1S/C8H18N2/c1-4-6-10(7-5-2)8(3)9/h9H,4-7H2,1-3H3 InChIKey=NCEHBEWJERYLDC-UHFFFAOYSA-N |
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| Novichok precursor | AG 80 | N,N-Dimethylpropanamidine | 56776-14-8 | 12375523 |
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CCC(=N)N(C)C | InChI=1S/C5H12N2/c1-4-5(6)7(2)3/h6H,4H2,1-3H3 InChIKey=HFNWYQJFWCTELT-UHFFFAOYSA-N |
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| Novichok precursor | AG 81 | N,N-Diethylpropanamidine | 84764-73-8 | 13109962 |
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CCN(CC)C(=N)CC | InChI=1S/C7H16N2/c1-4-7(8)9(5-2)6-3/h8H,4-6H2,1-3H3 InChIKey=KCIXJSPXBFPFGZ-UHFFFAOYSA-N |
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| Novichok precursor | AG 82 | N,N-Dipropylpropanamidine | 1341496-89-6 | 62047942 |
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CCCN(CCC)C(=N)CC | InChI=1S/C9H20N2/c1-4-7-11(8-5-2)9(10)6-3/h10H,4-8H2,1-3H3 InChIKey=QGXGUIYCSOPPGP-UHFFFAOYSA-N |
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| Novichok precursor | AG 83 | N,N-Dimethylbutanamidine | 1340437-35-5 | 17928752 |
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CCCC(=N)N(C)C | InChI=1S/C6H14N2/c1-4-5-6(7)8(2)3/h7H,4-5H2,1-3H3 InChIKey=XXHLECYBVSUVRK-UHFFFAOYSA-N |
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| Novichok precursor | AG 84 | N,N-Diethylbutanamidine | 53510-30-8 | 57106491 |
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CCCC(=N)N(CC)CC | InChI=1S/C8H18N2/c1-4-7-8(9)10(5-2)6-3/h9H,4-7H2,1-3H3 InChIKey=RFCZFRBWFIKGTJ-UHFFFAOYSA-N |
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| Novichok precursor | AG 85 | N,N-Dipropylbutanamidine | 1342422-35-8 | 62048118 |
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CCCN(CCC)C(=N)CCC | InChI=1S/C10H22N2/c1-4-7-10(11)12(8-5-2)9-6-3/h11H,4-9H2,1-3H3 InChIKey=LVXHITFMDGAYLY-UHFFFAOYSA-N |
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| Novichok precursor | AG 86 | N,N-Diisopropylbutanamidine | 1315467-17-4 | 101801650 |
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CCCC(=N)N(C(C)C)C(C)C | InChI=1S/C10H22N2/c1-6-7-10(11)12(8(2)3)9(4)5/h8-9,11H,6-7H2,1-5H3 InChIKey=IRABBLSJPFTRAG-UHFFFAOYSA-N |
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| Novichok precursor | AG 87 | N,N-Dimethylisobutanamidine | 321881-25-8 | 21623186 |
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CC(C)C(=N)N(C)C | InChI=1S/C6H14N2/c1-5(2)6(7)8(3)4/h5,7H,1-4H3 InChIKey=MNSQSJWQUTWSOO-UHFFFAOYSA-N |
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| Precursors (added Feb 2020) | AG 88 | N,N-Diethylisobutanamidine | 1342789-47-2 | 63178417 |
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CCN(CC)C(=N)C(C)C | InChI=1S/C8H18N2/c1-5-10(6-2)8(9)7(3)4/h7,9H,5-6H2,1-4H3 InChIKey=MMEVCRWGUFGFNT-UHFFFAOYSA-N |
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| Precursors (added Feb 2020) | AG 89 | N,N-Dipropylisobutanamidine | 1342700-45-1 | 62047940 |
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CCCN(CCC)C(=N)C(C)C | InChI=1S/C10H22N2/c1-5-7-12(8-6-2)10(11)9(3)4/h9,11H,5-8H2,1-4H3 InChIKey=RRTZRCMLILQTEC-UHFFFAOYSA-N |
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